Palmitoylethanolamide at https://www.cofttek.com/product/544-31-0/ can increase the effect of regular painkilling medicines. PEA protects the nerves in chemotherapy and has an anti-tumor effect. PEA is an interesting anti-inflammatory therapeutic substance and might also hold great promise for the treatment of some (auto) immune disorders, including inflammatory bowel disease and inflammatory diseases of the CNS.
The use of a complete nutritional approach seems increasingly promising to combat chronic inflammation. The option of sound sources of carbohydrates, fats, and proteins, correlated with normal physical exercise and delay of smoking is necessary to struggle the war facing chronic diseases.
At the bottom of the analgesic, anti-inflammatory, or antioxidant activity of the diets, there are various molecules, amidst which any of a lipidic essence very effective in the inflammatory pathway.
MORE ABOUT PALMITOYLETHANOLAMIDE:
One group of molecules discovered in diets with anti-inflammatory effects are ALIAmides. Amongst all, one is especially recognized for its capacity to prevent the inflammatory cascade, the Palmitoylethanolamide (PEA). PEA is molecular that is present in nature, in numerous foods, and is endogenously produced by our body, which acts as a balancer of inflammatory processes, also known as endocannabinoid-like.
PEA is frequently done in the operation of both acute and chronic inflammatory pathologies, either solely or in cooperation with another molecules with characteristics, such as antioxidants or analgesics. This review aims to illustrate an overview of the different diets that are involved in the process of opposition to the inflammatory cascade, focusing on the capacity of PEA.
MECHANISM OF ACTION OF PALMITOYLETHANOLAMIDE:
One of the mechanisms which the anti-inflammatory effect of PALMITOYLETHANOLAMIDE is observed is described below:
- PEA reduces mast cell migration and degranulation and reduces the pathological overactivation of these cells. Most cells displace from stimulated immune to relaxing phenotypes below control of PEA. PEA further reduces the activity of the pro-inflammatory enzymes, cyclooxygenase, and endothelial, and inducible nitric oxide synthases.
METABOLISM OF PALMITOYLETHANOLAMIDE:
In the body, PEA is synthesized from palmitic acid (C16:0), which is the most common fatty acid in animals and a product of normal fatty acid synthesis. Palmitic acid is additionally existing in multiple foodstuffs including palm tree oil, meats, cheeses, butter, and dairy commodities.
Synthesis of PEA takes place in membranes of various cell types and involves different steps and partly parallel pathways. The most studied pathway goes via N-palmitoyl-phosphatidyl-ethanolamine, which belongs to the class of N-acyl phosphatidylethanolamines (NAPEs).
Eventually, the efficiency of treatment of PEA suggests the probability like Pterostilbene to have a responsive therapeutic solution available in case of a flu epidemic, particularly in circumstances of a mismatch between distributing strains and the guidance from WHO.